I had a severe itch that was constant and sometimes nearly unbearable when I was going through my first chemotherapy triplet (Taxol, carboplatin, Avastin). It was worst on my hands and the soles of my feet, though it seemed to strike all parts of my body that experienced much friction for any reason. I did not have a rash at all and my medical team had no idea what to do about it. After trying some OTC lotions/creams that had no impact whatsoever, then trying Vitamin B supplements, I was put on Lyrica because I became convinced it was connected to the neuropathy I was experiencing. Even with that, the help I received from it seemed very minimal, at best.
Severe itching is very difficult to endure, for sure. Once my treatment with that triplet ended, so did the itching. I was so very, very thankful for that.