Margot
Have you received biomarker testing or discussed biomarker testing?
BobinTO Member
My partner had two.
The first was conducted on the tissue sample obtained from her biopsy in early January. It turned up nothing that would have made her a candidate for a targeted therapy.
The second was on a blood sample taken when she was admitted to the hospital and was paid for by a drug company conducting a clinical trial.
She spent a week in the hospital and received 5 days of radiation to shrink her brain mets. On the final day of treatment, she had a meeting with her “team” and was told there was nothing more that could be done for her. She could return home or go to a hospice and receive palliative care.
On the day before she was to be released, I call from a nurse on her floor. Her oncologist had visited and announced that there might be a treatment for her. He would call and explain.
Turns out he had just received the results from the blood test . it had turned up a mutation on axon 19 of the EGFR gene. He would start her on a drug that targeted that mutation the next day. She’s been on it for about 8 weeks now. She had a CT scan at the end of last month, and although it was not hi-res., the primary tumour appeared to be shrinking. So far there’s no indication the brain mets are growing back. She remains lucid and ambulatory, though still quite fatigued.
Alisa Moderator
BobinTO Member
The former.
The problem was, her cancer was diagnosed at a very advanced stage, with brain mets. By the time she was admitted, she had become paralyzed on one side. At that stage, there were only two options for treatment that would have offered her much hope: a targeted therapy or immunotherapy. The first had been ruled out because the hospital tests didn’t turn up any appropriate biomarkers. As for immunotherapy, it is only offered in our province on an out-patient basis – that didn’t seem possible given the physical condition she was in at the time.
Christine Qiong Wu Moderator
Looks like that EGFR drug is working for her. Let's watch and wait. How is the site-effects for her? Christine Moderator
BobinTO Member
Christine Qiong Wu Moderator
BobinTO, Although there is some clinical trials, generally EGFR lung cancer patients are not suitable for immunotherapy. Targeted therapy is a way to go. Are you from Canada? I'm a Canadian. After several months, things will be settled down. Christine lungcancer.net
chachmom Member
I received testing early in my diagnosis of Stage IV non small cell adenocarcinoma. In fact, after being found in hospital setting June 10, 2020. Pulmonary Doctor referred me to Oncologist. Got appointment ASAP. First visit set plan of chemotherapy. Blood draw was sent out for special testing…within a month and three chemo treatments….he changed chemo by removing one Med in prep for EGFR axon 19 taregeted therapy with Tagrisso ( pill a day)….third CT after diagnosis…my tumor has reduced in size by 2/3, nodules in three other areas have disappeared. Minimal side effects…I feel good and blessed!
Alisa Moderator
Michael79 Member