Skip to Accessibility Tools Skip to Content Skip to Footer

Xalkori (crizotinib)

Xalkori® is a targeted therapy that is used to treat some non-small cell lung cancers (NSCLC) that have a certain anaplastic lymphoma kinase (ALK) mutation. ALK mutation is determined by biomarker tests (molecular testing) conducted on a biopsy sample of the tumor. Crizotinib is an ALK inhibitor and is also classified as a kinase inhibitor. It is designed to block the activating sites (tyrosine kinases) of several proteins within the cancer cell. These proteins can stimulate cancer growth when the tumor has an ALK mutation. By blocking the proteins, crizotinib may shrink the cancer or slow the cancer’s progression.1,2

Crizotinib is used to treat NSCLC patients with a certain ALK gene mutation that has spread to other parts of the body (metastasized). Crizotinib is also used to treat patients with metastatic NSCLC that have an ROS1 mutation.1

About ALK mutations

An estimated 3-5% of lung tumors have mutations on the ALK gene, which stands for anaplastic lymphoma kinase. ALK mutations are more common in light smokers (defined as less than 10 pack years*) and/or never-smokers (patients are considered “never smokers” if they have smoked less than 100 cigarettes in their lifetime). These mutations are also associated with younger patient age and adenocarcinomas.4,5

Receiving crizotinib

Crizotinib is a capsule taken by mouth, and it can be taken with or without food usually twice daily. Xalkori capsules should be swallowed whole and should not be opened or crushed. The dosage is determined by several factors, including the patient’s general health, liver and kidney function, and ongoing response to treatment. Patients should not drink grapefruit juice or eat grapefruit during treatment with crizotinib, as it may increase the level of crizotinib in the blood to a harmful level. Patients should take their medication as prescribed by their doctor. Patients should talk to their doctor if they have any questions, or if they have questions regarding their crizotinib regimen.2

Side effects of crizotinib

Crizotinib may cause side effects, and in some cases, these side effects can be severe. Any side effects should be reported to a health care professional. Side effects experienced in greater than 30% of patients taking crizotinib include vision problems (such as blurred vision, double vision, or increased sensitivity to light), nausea, diarrhea, and vomiting. Less common side effects experienced in 10-29% of patients receiving Xalkori include swelling (edema), constipation, fatigue, decreased appetite, dizziness, increased liver enzymes, numbness or tingling in hands and feet, taste changes, heartburn, and rash. Rarely, crizotinib can cause severe side effects, and patients taking crizotinib should seek medical care immediately if they experience difficulty breathing with a cough or low-grade fever, slow heartbeat, or dizziness. Additional side effects that are not an emergency but require medical attention include frequent diarrhea (4-6 episodes within 24 hours), nausea, vomiting (more than 4-5 times within 24 hours), signs of dehydration (tiredness, dry mouth, dark and decreased urine, or dizziness), eye irritation, yellowing of the skin or whites of the eyes (jaundice), dark or brown urine, decreased appetite, pain on the right side of the stomach region, bleeding or bruising more than normal, itching, or coughing with or without mucus. This is not a complete list of side effects.1,2

Precautions

Patients receiving crizotinib should talk to their doctor about other medications, herbal remedies, and any supplements they are taking, as well as any other health conditions. Patients should talk to their doctor before receiving immunizations or vaccinations while taking crizotinib to make sure they are appropriate. Patients who are pregnant or may become pregnant during treatment should discuss their condition with their doctor prior to starting crizotinib, as it may be hazardous to the fetus. It is not recommended for men or women to conceive a child while taking crizotinib, and patients are advised to use barrier methods of contraception (i.e. condoms). It is not known whether crizotinib passes into breast milk, and patients should not breastfeed while taking crizotinib.2

*Pack years is a term used to help quantify the equivalent of how many years a patient has smoked.  It is calculated by multiplying the number of packs of cigarettes smoked per day by the number of years the person has smoked. For example, smoking one pack per day for one year equals 1 pack year, whereas smoking two packs per day for two years equals 4 pack years.

Written by: Emily Downward | Last reviewed: April 2019.
  1. Xalkori product website, Pfizer, Inc. Accessed online on 9/28/16 at http://www.xalkori.com/.
  2. Chemocare. Accessed online on 9/28/16 at http://chemocare.com/chemotherapy/drug-info/Xalkori-capsules.aspx.
  3. My Cancer Genome. Accessed online on 8/14/16 at https://www.mycancergenome.org/.
  4. Genetics Home Reference, National Institutes of Health. Accessed online on 8/2/16 at https://ghr.nlm.nih.gov/.