Skip to Accessibility Menu Skip to Login Skip to Content Skip to Footer

Rybrevant (amivantamab-vmjw)

Editorial Team's avatar image

By Editorial Team

2 min read

Reviewed by: HU Medical Review Board | Last reviewed: September 2023 | Last updated: September 2023

RybrevantTM (amivantamab-vmjw) is a drug used to treat adults with non-small cell lung cancer (NSCLC) that:1

  • Has spread to other parts of the body (metastatic) or is locally advanced (cancer has progressed within the lung region), and
  • Has epidermal growth factor receptor (EGFR) exon 20 insertion mutations, and
  • Whose disease has worsened while on or after receiving platinum-based chemotherapy

The Guardant360 CDx is a companion diagnostic used with Rybrevant. A companion diagnostic can help determine which people are right for therapy based on tumor characteristics.1,2

ANSCLC makes up about 80 to 85 percent of all lung cancers. About 2 or 3 percent of people with NSCLC have EGFR exon 20 insertion mutations. These mutations allow the cancer to grow and spread.1

By providing your email address, you are agreeing to our Privacy Policy and Terms of Use.

What are the ingredients in Rybrevant?

The active ingredient in Rybrevant is amivantamab-vmjw.1

How does Rybrevant work?

Rybrevant is a monoclonal antibody. A monoclonal antibody is a specific immune system protein that is made in a lab. Rybrevant targets 2 proteins that help cancer grow: EGFR and MET. Rybrevant binds to these proteins, which can help slow the growth of cancer cells and cause them to die.1-4

What are the possible side effects of Rybrevant?

The most common side effects of Rybrevant include:1,4

  • Rash
  • Infected skin around the nail
  • Muscle and joint pain
  • Shortness of breath
  • Nausea, vomiting
  • Tiredness
  • Swelling
  • Mouth sores
  • Cough
  • Constipation
  • Changes in certain blood tests

These are not all the possible side effects of Rybrevant. Talk to your doctor about what to expect when taking Rybrevant. You also should call your doctor if you have any changes that concern you when taking Rybrevant.

Things to know about Rybrevant

Before taking Rybrevant, tell your doctor if you have a history of lung or breathing problems.1,4

Rybrevant can cause skin reactions. Limit sun exposure while taking Rybrevant and for 2 months after treatment is completed. Use a broad-spectrum UVA/UVB sunscreen. Wear protective clothing while in the sun.1,4

Rybrevant can harm an unborn baby. If you can become pregnant, you should use birth control during treatment and for some time after the last dose of Rybrevant. You should also not breastfeed during treatment with Rybrevant and for some time after the last dose. Talk to your doctor about your options for birth control and breastfeeding while taking Rybrevant.1,4

Before beginning treatment for lung cancer, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Rybrevant.