Portrazza (necitumumab)

Written by: Emily Downward | Last reviewed: July 2022 | Last updated: October 2022

Portrazza® is approved as initial treatment in combination with chemotherapy drugs gemcitabine and cisplatin for patients with metastatic (spread to distant parts of the body) squamous non-small cell lung cancer (NSCLC). Necitumumab is a targeted therapy that is classified as a monoclonal antibody.1,2

Antibodies are a normal part of the immune system that attach to antigens (such as germs) to mark them for destruction by the immune system. Monoclonal antibodies used in cancer treatment are created in a laboratory to attach to specific antigens on the surface of cancer cells. Necitumumab is a monoclonal antibody that attaches to EGFR (epidermal growth factor receptors) and is an EGFR antagonist (blocks the EGFR pathway to inhibit cancer growth).1,2

About EGFR

EGFR is one of several receptor tyrosine kinases (RTKs). RTKs are cell-surface receptors that partner with ligands, proteins that activate the receptor to cause a specific action in the cell. In its normal capacity, EGFR triggers cell growth and division. When there is a mutation to the EGFR gene, such as is found in many cancer cells, the malignant (cancerous) cells are activated to divide, grow faster, and survive.3-5

Receiving necitumumab

Necitumumab is given as an infusion through an IV (intravenous) line. The dosage is determined by several factors, including the patient’s general health and ongoing response to treatment.2

Side effects of necitumumab

Necitumumab may cause side effects, and in some cases, these side effects can be severe. Any side effects should be reported to a health care professional. Side effects experienced in greater than approximately 30 percent of patients receiving necitumumab include skin reactions (rash, dry skin, itching, and/or redness) and lowered amounts of magnesium, calcium, and phosphorous in the blood. Less common side effects experienced in approximately 10 to 29 percent of patients receiving necitumumab include vomiting, diarrhea, acne, weight loss, mouth sores, coughing up blood, and lowered amounts of potassium in the blood.2

Rarely, necitumumab can cause severe side effects, including serious heart and lung events. Patients taking necitumumab should seek medical care immediately if they experience any of the following symptoms: fever of 100.4°F or higher, mood changes, confusion, muscle pain or weakness, a heartbeat that feels abnormal, seizures, not feeling hungry, bad stomach upset, weakness on one side of the body, difficulty speaking or thinking, changes in balance, blurred eyesight, dizziness, passing out, or signs of a blood clot, such as chest pain, pressure, coughing up blood, shortness of breath, or swelling, warmth, numbness or pain in a leg or arm.2

These are not all of the potential side effects of necitumumab. Talk to your healthcare provider or pharmacist for further information.


Patients receiving necitumumab should talk to their doctor about any other medications (prescription and over-the-counter), herbal remedies, and any supplements they are taking, as well as any other health conditions. If you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed, talk with your doctor. Necitumumab can cause harm to a developing fetus and should not be given to people who are pregnant.2

While receiving necitumumab, people who can become pregnant should use contraceptives during treatment and for a period of time after completing treatment. Discuss appropriate birth control methods, and how long you need to use them, with your doctor. Women should not breastfeed during necitumumab treatment and for a period of time following the final dose. Discuss breastfeeding considerations with your doctor. Talk to your doctor if you have any questions about necitumumab.2

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