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Mvasi (bevacizumab-awwb)

Mvasi™ is a biosimilar to Avastin® (bevacizumab) and like Avastin, it is approved to treat adults with certain types of brain, kidney, cervical, colorectal, and lung cancers. Specifically, in lung cancer, Mvasi is approved to treat non-squamous non-small cell lung cancer (NSCLC) in combination with carboplatin and paclitaxel for first-line treatment of tumors that cannot be operated on (unresectable), are locally advanced, or recurrent or metastatic disease.1

What are the ingredients in Mvasi?

Mvasi is a biosimilar to bevacizumab. As a biological product, it is made from a living organism (may be human, animal, bacteria, or yeast).1,2

How does Mvasi work?

Like Avastin, Mvasi is a recombinant immunoglobulin G1 (IgG1) monoclonal antibody that binds to and inhibits vascular endothelial growth factor (VEGF). By blocking VEGF, Mvasi inhibits the growth of new blood vessels, which are necessary for the growth of solid tumors.1,3

What are the possible side effects of Mvasi?

In clinical trials, the most common side effects experienced by people receiving Mvasi were nose bleeds (epistaxis), headache, high blood pressure (hypertension), inflammation of the nasal cavity (rhinitis), high levels of protein in the urine (proteinuria), taste alteration, dry skin, rectal bleeding (hemorrhage), excessive tear production (lacrimation disorder), back pain and skin irritation (exfoliative dermatitis).1

Some people taking Mvasi have experienced serious side effects such as:

  • Perforation (holes) in the gastrointestinal tract
  • Surgery and wound healing complications
  • Hemorrhage (severe bleeding), which may occur as pulmonary (lungs), gastrointestinal, central nervous system, or vaginal bleeding and may be fatal1

Other serious side effects that may occur with Mvasi include holes in or abnormal connection between two organs (perforation or fistula), blood clot formation (arterial and venous thromboembolic events), hypertension, problems in brain function or structure (posterior reversible encephalopathy syndrome), high levels of protein in the urine (proteinuria), infusion-related reactions and loss of function of the ovaries (ovarian failure). Mvasi should be discontinued if certain of these side effects occur or if these side effects become life-threatening.1 This is not a complete list of adverse side effects.

Things to know about Mvasi

Mvasi should not be used by pregnant women as Mvasi may cause harm to a developing fetus. Women of reproductive age should use contraception while taking Mvasi and for six months after their last dose of Mvasi. Mvasi may impair fertility.1

Breastfeeding is not recommended during treatment with Mvasi.1

Mvasi should not be used for at least 28 days prior to major surgery and for at least 28 days following major surgery, as it can delay the healing of surgical wounds.1 Tell your doctor about all health conditions, medications, and health history when discussing Mvasi as a treatment option.

Dosing information

Mvasi is given as an intravenous (IV) infusion. Patients should talk to their doctor if they have questions regarding their Mvasi treatment.1

For more information, read the full prescribing information for Mvasi.

Written by: Emily Downward | Last reviewed: January 2020.
1. Mvasi prescribing information. Available at Accessed 10/3/17. 2. Amgen Biosimilars. Available at Accessed 10/3/17. 3. Amgen press release. Available at Accessed 10/3/17.