Cyramza (ramucirumab)

Reviewed by: HU Medical Review Board | Last reviewed: August 2023 | Last updated: August 2023

Cyramza® (ramucirumab) is a targeted therapy that is used to treat some adults with non-small cell lung cancers (NSCLC). Cyramza may be used:1

  • Along with erlotinib for first-line treatment of NSCLC that:
    • Has spread (metastatic) and
    • Has epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) mutations
  • Along with docetaxel for NSCLC that has gotten worse during or after treatment with platinum-based chemotherapy
Your doctor will perform a genetic test to find out whether Cyramza is right for you.What are the ingredients in Cyramza?The active ingredient in Cyramza is ramucirumab.1How does Cyramza work?Cyramza is an EGFR inhibitor. It is designed to block the activating sites (tyrosine kinases) of certain proteins found in cancer cells. These proteins can stimulate cancer growth when the tumor has an EGFR mutation. By blocking how the proteins work, Cyramza may shrink the cancer or slow down its growth.1What are the possible side effects?The most common side effects of Cyramza used along with erlotinib include:1InfectionsHigh blood pressureSwelling and sores inside the mouthProtein in the urineHair lossNosebleedThe most common side effects of Cyramza used along with docetaxel include:1Low white blood cell countsTiredness, weaknessSwelling and sores inside the mouthThese are not all the possible side effects of Cyramza. Talk to your doctor about what to expect when taking Cyramza. You also should call your doctor if you have any changes that concern you when taking Cyramza.Other things to knowBefore starting treatment with Cyramza, tell your doctor if you have:1Any condition that increases the risk of bleedingHigh blood pressureAn upcoming surgery, had recent surgery, or a poorly healing wound after surgeryLiver problems, such as cirrhosis or ascitesBlood clots in your arteriesA history of heart attack or strokeA history of holes in your stomach or bowelHeart problemsCyramza can harm an unborn baby. If you can become pregnant, you should use birth control during treatment and for some time after the last dose of Cyramza. You should also not breastfeed during treatment with Cyramza and for some time after the last dose. Talk to your doctor about your options for birth control and breastfeeding while taking Cyramza.1Before beginning treatment for lung cancer, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.For more information, read the full prescribing information of Cyramza.

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